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KMID : 0605720140200030201
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Journal of the Korean Society of Biological Therapies in Psychiatry
2014 Volume.20 No. 3 p.201 ~ p.211
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The Association between Serum Testosterone Level and Cognitive Function in Men with Chronic Schizophrenia
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Kim Woo-Rim
Suh Jae-Won
Lee Kyung-Han
Kim Shin-Kyum
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Abstract
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Objectives：The purpose of this study was to investigate the relationships between sexual hormone level and cognition in male patients with schizophrenia.
Methods：Total 80 male patients with schizophrenia were involved in this study. Among them, 61 patients were classified into normal cognition group(NCG) and 19 patients for lower cognition group(LCG), according to the Korean version of Consortium to Establish a Registry for Alzheimer’s Disease(CERAD-K) and Korean-Color Word Stroop Test. LCG was identified who were included at the below 5 percentile in at least one domain of the cognitive test. All the participants completed Positive and Negative Syndrome Scale(PANSS), Simpson Angus rating Scales(SAS) and Hamilton rating scale for Depression(HAM-D). Sexual hormone levels of prolactin, total testosterone, free-testosterone and estradiol were also checked by blood hormonal assays.
Results：The patients with higher total testosterone level on construction domain were more likely to be included in LCG than NCG. Statistically significant correlations were still observed after adjustment of the several covariants. Total testosterone, free testosterone and estradiol levels have statistically significant positive correlations between each other, but there were negative correlations between prolactin and other hormone levels in 80 male patients with schizophrenia.
Conclusion：These results suggest that sexual hormone may modulate the cognitive deficits in patients with chronic schizophrenia. Sexual hormone levels would be considered as predictive factors about cognitive function of patients with chronic schizophrenia. Furthermore, longitudinal and large-scale control studies would be needed to confirm these results.
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KEYWORD
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Chronic schizophrenia, Cognitive function, Total testosterone
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